I am of a mind that one should use every tools available these days when surfing the web. 90% of websites scan everyone automatically in an effort to find info they can "make money" with by selling to others who will use it against you, or at the very least will take your 'valid' e-mail addy and sell it to the spammers (for one).
I use over 12 "anti" everythings ALL THE TIME (realtime), and my systems are set to scan everything I have twice daily. Even with all of the high-tech protection I am running, there is always somebody who manages to break through it in an attempt to leave a nasty on my systems, which irks me to no end.
I use everything that DiamondCS uses ...their latest programme, Process Guard is a killer, yet Microsoft's new Antispyware contends with it since they both are "watching out" in realtime ...which is a plus. SpyWare Guard from JavaCool is priceless, MRU-Blaster, SpyBot and SpyWareBlaster (with Tea-Timer) to prevent all manner of bad things (like browser hijackings), TDS-3 allows me to track anyone who 'gets funny' with me plus it is loaded with features (including "lookup" capabilities that are priceless. Zone Alarm Pro works fine for me without causing any loss in speed, and I've had great luck with McAfee (their best). Once a month I visit
www.trendmicro.com and let them do a full scan just to be safe, and every once in a while I'll go to PC Pitstop and let them put me through their wringer to make sure I'm running at optimum. All these things combine make for peace of mind and a secure system. My very best defence (or defense if you will), is Steganos Security Suite 7. It erases all tracks and has excellent features that are unrivaled by any other programme trying to imitate it. I also 'swear by" being anonymous while online, and that's why I have dual accounts (
www.proxify.net and
www.anonymizer.com). Using either of them, no matter where you go you are safe. They can only attack your anonymizer ...you are well out of harm's reach! Oh, I also am running Trojan Hunter now and it's a hot programme too!
I take this machine in the 'meanest' of places yet nobody has been able to trash me (lately) since the installation of all this "protection" software. Before, I was reformatting all the time due to some egghead getting off on trashing my system just because they thought it was "cool." Now ..if they even try, it's detected and my programmes lead me right to him no matter how well he's tried to hide himself (and then they get a taste of their own medicine).

lol....
"The Rev"